PXD083168-1

PXD083168 is an original dataset announced via ProteomeXchange.

Title	SLC25A18 deficiency promotes cholangiocarcinoma progression and gemcitabine resistance by impairing TGFBR1 ubiquitination and degradation
Description	TMT-based quantitative proteomic analysis Protein lysates were extracted from SLC25A18‑overexpressing HUCCT1 cells and corresponding control cells. Equal amounts of protein were reduced, alkylated, and digested with trypsin. The resulting peptides were labelled with TMT 6‑plex reagents, combined, and fractionated by high‑pH reversed‑phase HPLC. Each fraction was analysed by LC‑MS/MS on a Q Exactive HF‑X mass spectrometer. Raw spectra were searched against the UniProt human database using Proteome Discoverer, with peptide and protein identifications filtered at 1% FDR.
HostingRepository	iProX
AnnounceDate	2026-08-24
AnnouncementXML	Submission_2026-09-10_01:45:11.973.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Baohua Hou
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2026-08-25 18:24:00	ID requested
⏵ 1	2026-09-10 01:45:12	announced

Dataset with its publication pending

submitter keyword: SLC25A18, Cholangiocarcinoma, Gemcitabine resistance, TGFBR1, Ubiquitination degradation

Baohua Hou
contact affiliation	Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University
contact email	hbh1000@126.com
lab head
Baohua Hou
contact affiliation	Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University
contact email	hbh1000@126.com
dataset submitter

iProX dataset URI