⮝ Full datasets listing
PXD082969-1
PXD082969 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Monocyte phosphoproteomics for mechanosensory shear stress |
| Description | Calcific aortic valve disease (CAVD) exposes circulating monocytes to pathological haemodynamic forces before tissue infiltration, yet the molecular mechanisms by which these forces regulate inflammatory signalling remain poorly understood. Using our established microfluidic model of aortic stenosis, human monocytes were exposed to physiological or pathological shear stress. Quantitative proteomic and phosphoproteomic analyses identified mechanosensitive pathways activated by pathological shear stress, which were validated in primary human monocytes and paired monocytes isolated from patients with CAVD before and after transcatheter aortic valve implantation (TAVI). Perseus (v2.0.7.0) used for global proteomics and phosphoprotoemics data analysis. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-08-23 |
| AnnouncementXML | Submission_2026-08-23_19:36:08.580.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | David Greening |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Acetyl |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-08-21 11:37:00 | ID requested | |
| ⏵ 1 | 2026-08-23 19:36:09 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Monocyte, phosphoproteomics, mechanosensory, shear stress, DatasetType:Proteomics |
Contact List
| David Greening | |
|---|---|
| contact affiliation | Baker Heart & Diabetes Institute |
| contact email | david.greening@baker.edu.au |
| lab head | |
| David Greening | |
| contact affiliation | Baker Heart & Diabetes Institute |
| contact email | david.greening@baker.edu.au |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v14/MSV000102937/ |
