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PXD082835-1
PXD082835 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | A nonenveloped arbovirus reprograms migrasomes into highly infectious viral delivery units |
| Description | Nonenveloped viruses are generally thought to disseminate as individual naked particles released after cell lysis. Here, we show that bluetongue virus (BTV), a nonenveloped arbovirus, can instead disseminate before overt cell lysis as infectious units associated with migrasomes. These structures, which we term BTV-migrions, package multiple virions together with selected viral RNAs and replication-associated proteins, thereby delivering coordinated viral cargo rather than isolated virions. This composite cargo accelerates viral replication in recipient cells. Moreover, enclosure within a host-derived migrasome membrane enhances viral attachment and entry and protects virions from antibody-mediated neutralization. Mechanistically, the BTV core protein VP7 promotes migrasome biogenesis through RGD-dependent activation of integrin α5β1, whereas an actin-myosin Va transport module facilitates the selective loading of viral cargo. Together, these findings identify migrasomes as virus-exploited transmission organelles and reveal a previously unrecognized nonlytic dissemination strategy through which a nonenveloped arbovirus generates protected, highly infectious cargo-delivery units. |
| HostingRepository | iProX |
| AnnounceDate | 2026-08-18 |
| AnnouncementXML | Submission_2026-08-19_03:37:55.545.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Wenmin Tian |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-08-19 03:35:54 | ID requested | |
| ⏵ 1 | 2026-08-19 03:37:56 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Bluetongue virus (BTV), Migrasomes, Nonenveloped viruses |
Contact List
| Yang Chen | |
|---|---|
| contact affiliation | The Center for Precision Medicine Multi-omics Research (CPMMR) |
| contact email | chenyang1816185048@bjmu.edu.cn |
| lab head | |
| Wenmin Tian | |
| contact affiliation | The Center for Precision Medicine Multi-omics Research (CPMMR) |
| contact email | tianwenmin2019@126.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
