⮝ Full datasets listing
PXD082693-1
PXD082693 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Tracing the evolutionary trajectory of proteome profiles in TNBC cells under prolonged Chidamide exposure |
| Description | Triple-negative breast cancer (TNBC) represents the most aggressive subtype of breast cancer, which remains the most prevalent malignancy worldwide. Currently, TNBC lacks specific therapeutic targets. Histone deacetylases (HDACs) are aberrantly overexpressed in various tumors, including TNBC; consequently, HDAC inhibitors have demonstrated anti-tumor efficacy and the potential to reverse drug resistance. Chidamide is the first HDAC inhibitor globally approved for the clinical treatment of solid tumors. However, its clinical efficacy in TNBC patients remains unclear or controversial, primarily due to the absence of predictive biomarkers. Moreover, the development of drug resistance and toxicity at high concentrations have further limited its clinical application. Hence, tracing the evolutionary trajectory of proteome profiles in cancer cells under prolonged drug exposure was performed to explore potential vulnerabilities induced by a series of Chidamide treatments, as well as corresponding combination strategies. |
| HostingRepository | iProX |
| AnnounceDate | 2026-08-14 |
| AnnouncementXML | Submission_2026-08-17_03:44:45.674.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yanxia Zhang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-08-17 03:41:17 | ID requested | |
| ⏵ 1 | 2026-08-17 03:44:46 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Evolutionary trajectory, Proteome, Triple-negative breast cancer (TNBC) , Histone deacetylases (HDACs), Chidamide |
Contact List
| Yanxia Zhang | |
|---|---|
| contact affiliation | The Affiliated Qingyuan Hospital (Qingyuan People’s Hospital) |
| contact email | 2022695022@gzhmu.edu.cn |
| lab head | |
| Yanxia Zhang | |
| contact affiliation | The Affiliated Qingyuan Hospital (Qingyuan People’s Hospital) |
| contact email | 2022695022@gzhmu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
