⮝ Full datasets listing
PXD082211-1
PXD082211 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Biomarkers Correlating With the Development of Oral Squamous Cell Carcinoma From Leukoplakia |
| Description | We assessed protein biomarkers expressed in oral leukoplakia (OL) that are associated with the risk of transformation into oral squamous cell carcinoma (OSCC). Tissue sections of OL transforming into OSCC (leuko ca), the corresponding OSCC and OL that did not progress to OSCC (leuko- nonca) were analyzed with global relative quantification to compare proteome profiles. Immunohistochemistry was performed to validate the expression of identified biomarkers. Results: The top enriched biological pathways in OL transforming into OSCC within 5to26 months after diagnosis (short duration SD leuko ca) compared with leuko nonca were pathways regulating remodeling of the extracellular matrix (ECM) and lipid and cholesterol metabolism/transport. Kininogen- 1, apolipoprotein E (ApoE), collagen alpha 1 (XVIII) chain (COL18A1), sortilin, and perlecan were the most downregulated proteins, whereas EEF1D was the most upregulated in SD leuk- ca com pared with leuko nonca. Immunohistochemistry confirmed the expression of kininogen1, ApoE, perlecan, and EEF1D in OL and OSCC. In OSCC compared with leuko ca, enriched biological pathways involved keratinocyte and epithelial differentiation and immune response regulation. We identified biomarkers in OL that were associated with the risk of malignant transformation. Our study gives further support for the importance of the immune system, ECM remodeling, and lipoproteins and cholesterol metabolism in the progression of OL to OSCC |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-08-05 |
| AnnouncementXML | Submission_2026-08-05_06:19:11.147.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Annika Thorsell |
| SpeciesList | scientific name: human; |
| ModificationList | Oxidation; TMTpro; Carbamidomethyl |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-08-05 06:05:01 | ID requested | |
| ⏵ 1 | 2026-08-05 06:19:11 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Oral Squamous Cell Carcinoma, Leukoplakia, Biomarkers, Proteomics, DatasetType:Proteomics |
Contact List
| Daniel Giglio | |
|---|---|
| contact affiliation | Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg |
| contact email | daniel.giglio@pharm.gu.se |
| lab head | |
| Annika Thorsell | |
| contact affiliation | Proteomic core facility, Gothenburg universitet |
| contact email | annika.thorsell@gu.se |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v14/MSV000102731/ |
