PXD082044-1

PXD082044 is an original dataset announced via ProteomeXchange.

Title	Ponicidin inhibits colorectal cancer cell proliferation and induces apoptosis through modulating the ROS–p53 positive feedback loop via p53 targeting
Description	Colorectal cancer (CRC) is a common gastrointestinal malignancy with incidence and mortality rates ranking among the highest of all cancers, and patients generally have a poor prognosis. Current standard clinical treatments primarily include surgical resection, radiotherapy, and chemotherapy; however, surgery is only applicable to localized lesions and offers limited efficacy for metastatic or advanced-stage patients. Although chemotherapeutic agents such as 5-fluorouracil, capecitabine, and oxaliplatin can inhibit tumor progression, they are frequently associated with severe adverse effects. In recent years, traditional Chinese medicine and its active components have demonstrated potential in antitumor research through multi-target, multi-pathway synergistic effects, with relatively lower toxicity and side effects. Ponicidin (PON), a diterpenoid compound extracted from the traditional Chinese herb Rabdosia rubescens, has been confirmed to exert significant growth-inhibitory effects against various malignancies. Nevertheless, the specific molecular mechanisms underlying its action in colorectal cancer remain incompletely elucidated. This study aims to systematically evaluate the antitumor efficacy of PON against colorectal cancer and to deeply reveal its related molecular mechanisms, thereby providing experimental evidence for the further development and clinical application of PON.
HostingRepository	iProX
AnnounceDate	2026-07-31
AnnouncementXML	Submission_2026-08-03_00:10:41.575.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dan Ren
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2026-08-03 00:10:23	ID requested
⏵ 1	2026-08-03 00:10:42	announced

Dataset with its publication pending

submitter keyword: Colorectal cancer

Ponicidin

ROS-p53 feedback loop

Apoptosis

Epithelial–mesenchymal transition

Wenhu Liu
contact affiliation	North Sichuan Medical College
contact email	wh_liu2003@163.com
lab head
Dan Ren
contact affiliation	North Sichuan Medical college
contact email	13518479718@163.com
dataset submitter

iProX dataset URI