PXD081963-1

PXD081963 is an original dataset announced via ProteomeXchange.

Title	Mannose-Modified Lipid Nanoparticles Loaded with siZDHHC9 Remodel the Ras-ERK Signaling Axis in Antigen-Presenting Cells to Correct Th17/Treg Imbalance and Alleviate Fusobacterium nucleatum-Driven Ulcerative Colitis
Description	Fusobacterium nucleatum-induced ulcerative colitis (UC) is characterized by persistent intestinal inflammation and an imbalance in immune homeostasis, in which abnormal activation of antigen-presenting cells (APCs) and a Th17/Treg imbalance play critical roles in disease progression. This study aimed to construct the mannose-modified lipid nanoparticles (LNPs) loaded with siZDHHC9 (Man-LNP@siZDHHC9). By integrating single-cell RNA sequencing (scRNA-seq) and multi-omics technologies, we systematically elucidated the molecular mechanisms by which Man-LNP@siZDHHC9 remodels APC-T cell interactions by inhibiting the HRas palmitoylation-mediated ERK signaling axis, thereby ameliorating Th17/Treg imbalance and alleviating Fusobacterium nucleatum-induced UC.
HostingRepository	iProX
AnnounceDate	2026-07-31
AnnouncementXML	Submission_2026-07-31_00:23:32.482.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Siwei Wang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2026-07-31 00:23:15	ID requested
⏵ 1	2026-07-31 00:23:32	announced

Dataset with its publication pending

submitter keyword: Ulcerative Colitis

Shanling Xu
contact affiliation	Affiliated Cancer Hospital to University of Electronic Science and Technology of China
contact email	xushanling@scszlyy.org.cn
lab head
Siwei Wang
contact affiliation	Affiliated Cancer Hospital to University of Electronic Science and Technology of China
contact email	1545559471@qq.com
dataset submitter

iProX dataset URI