⮝ Full datasets listing
PXD081960-1
PXD081960 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Data-independent acquisition proteomic profiling of left ventricular myocardium from HFD/L-NAME-induced HFpEF mice |
| Description | This project contains the cardiac proteomic dataset generated from a mouse model of heart failure with preserved ejection fraction (HFpEF). Male C57BL/6J mice were subjected to a dual-hit HFpEF protocol consisting of a high-fat diet and L-NAME administration, whereas age-matched control mice received standard chow and normal drinking water. Left ventricular myocardial tissues were collected and analyzed using data-independent acquisition liquid chromatography-tandem mass spectrometry. The study was designed to characterize HFpEF-associated alterations in the cardiac proteome and to identify upstream regulators of metabolic and mitochondrial remodeling. Differentially expressed proteins were primarily associated with fatty acid metabolism, mitochondrial organization, energy homeostasis, oxidative stress, and pathological cardiac remodeling. Integrated analysis identified oxidative stress-responsive kinase 1 (OXSR1) as a candidate pathogenic regulator associated with mitochondrial dysfunction and metabolic remodeling in HFpEF myocardium. |
| HostingRepository | iProX |
| AnnounceDate | 2026-07-30 |
| AnnouncementXML | Submission_2026-07-31_00:18:16.329.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Kai Huang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ Orbitrap Elite |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-07-31 00:17:56 | ID requested | |
| ⏵ 1 | 2026-07-31 00:18:16 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: HFpEF, cardiac proteomics, DIA mass spectrometry, mouse heart, OXSR1, mitochondrial dysfunction, fatty acid metabolism, oxidative stress, diastolic dysfunction |
Contact List
| Lin Han | |
|---|---|
| contact affiliation | Changhai Hospital |
| contact email | sh_hanlin@hotmail.com |
| lab head | |
| Kai Huang | |
| contact affiliation | Changhai Hospital |
| contact email | drhuangkai@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
