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PXD081843-1
PXD081843 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Integrative peptidomics and proteomics profiling of plasma-derived extracellular vesicles reveals molecular signatures of SLE and LN |
| Description | Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease for which non-invasive stratification of lupus nephritis (LN) remains challenging. Here, we integrated antibody-based enrichment of plasma-derived extracellular vesicles (EVs) with label-free peptidomic and proteomic profiling in a discovery cohort of 45 individuals comprising healthy controls, SLE without nephritis (SLE LN−), and SLE with nephritis (SLE LN+). A total of 472 endogenous peptides and 3,111 proteins were quantified. The EV proteome predominantly captured SLE-associated immune, complement-coagulation, and platelet signatures, whereas the endogenous peptidome exhibited greater discriminatory power for renal involvement. Compared with SLE LN− patients, SLE LN+ patients displayed 296 differentially expressed peptides, including 245 peptides specifically associated with LN-related comparisons. To verified the reproducibility and clinical relevance of EV molecular signatures, targeted multiple reaction monitoring (MRM) was perfor |
| HostingRepository | iProX |
| AnnounceDate | 2026-07-28 |
| AnnouncementXML | Submission_2026-07-29_01:47:40.293.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Dong Wei |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | ZenoTOF 7600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-07-29 01:46:31 | ID requested | |
| ⏵ 1 | 2026-07-29 01:47:40 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Systemic Lupus Erythematosus, Lupus Nephritis, Peptidomics, Extracellular vesicles, Mass Spectrometry |
Contact List
| Dong Wei | |
|---|---|
| contact affiliation | Fuyao University of Science and Technology |
| contact email | dweimj@fyust.edu.cn |
| lab head | |
| Dong Wei | |
| contact affiliation | Fuyao University of Science and Technology |
| contact email | dweimj@fyust.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
