PXD081746-1

PXD081746 is an original dataset announced via ProteomeXchange.

Title	Serum DIA proteomic profiling of primary Sjögren’s syndrome with comorbid anxiety (integrated with metabolomics deposited in MetaboLights)
Description	Primary Sjögren’s syndrome (pSS) is frequently complicated by anxiety disorder, which severely impairs patients’ quality of life, yet the underlying pathogenesis remains elusive. This study aimed to characterize the serum molecular signatures of pSS patients with comorbid anxiety through an integrated analysis of untargeted metabolomics and DIA-based quantitative proteomics. Serum samples from 26 pSS patients with anxiety disorder and 30 healthy control subjects were analyzed. This iProX project only contains the DIA quantitative serum proteomics dataset of this study. The corresponding untargeted metabolomics raw data have been deposited in MetaboLights. One subproject is included in this project, corresponding to all serum proteomic raw files and processed results acquired by data-independent acquisition (DIA) LC-MS/MS.
HostingRepository	iProX
AnnounceDate	2026-07-27
AnnouncementXML	Submission_2026-07-28_00:28:36.164.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Li Wang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Astral

Revision	Datetime	Status	ChangeLog Entry
0	2026-07-28 00:28:01	ID requested
⏵ 1	2026-07-28 00:28:36	announced

Dataset with its publication pending

submitter keyword: Primary Sjögren‘s syndrome, anxiety disorder, proteomics, serum, DIA, autoimmune

Jinmei Zhou
contact affiliation	Mianyang Central Hospital
contact email	letter.zjm@163.com
lab head
Li Wang
contact affiliation	Department of Rheumatology and Immunology, Mianyang Central Hospital
contact email	1743708981@qq.com
dataset submitter

iProX dataset URI