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PXD081643-1

PXD081643 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHeparin-Sephacryl S200HR resin enables high-purity enrichment of plasma-derived extracellular vehicles (EVs) and ApoB-containing lipoprotein nanoparticles
DescriptionProteomic characterization of EVs and ApoB lipoprotein nanoparticles isolated via DP-SEC .We isolated EV and ApoB lipoprotein nanoparticles from plasma using DP-SEC. To achieve a more comprehensive analysis, we performed quantitative proteomic profiling to compare these fractions. The experimental design included four groups: FLDL: ApoB-containing lipoprotein fraction isolated by DP-SEC (Figure 2, F29--F32), FsEV: EV fraction isolated by DP-SEC (Figure 2, F34--F37), FALB: Albumin-rich fraction isolated by DP-SEC (Figure 2, F39--F46), sEVUC: Plasma EVs isolated by differential ultracentrifugation (dUC). Our proteomic analysis identified 3562 items (proteins or peptides) across all groups , with the following overlap: FsEV shared 98.93% (3517/3562) proteins with sEVUC, and FsEV shared 88.61% (3144/3562) of proteins with FALB.
HostingRepositoryMassIVE
AnnounceDate2026-07-26
AnnouncementXMLSubmission_2026-07-26_18:43:42.019.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterLi zonxin
SpeciesList scientific name: human;
ModificationListunknown modification
Instrumentinstrument model
Dataset History
RevisionDatetimeStatusChangeLog Entry
02026-07-25 02:50:19ID requested
12026-07-26 18:43:42announced
Publication List
no publication
Keyword List
submitter keyword: EVs, ApoB lipoprotein nanoparticles, DP-SEC, human plasma, DatasetType:Proteomics
Contact List
Kun Deng
contact affiliationThe Third Affiliated Hospital of Chongqing Medical University
contact emaildengkun@hospital.cqmu.edu.cn
lab head
Li zonxin
contact affiliationThe Third Affiliated Hospital of Chongqing Medical University
contact email980799943@qq.com
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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