⮝ Full datasets listing
PXD081602-1
PXD081602 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Arsenic targets KMT2A::AF6 in t(6;11) AML via PML bodies |
| Description | Mass spectrometry-based label-free DIA-PASEF proteomic analysis of nuclear protein extracts from acute myeloid leukemia models harboring either the t(6;11) KMT2A::AFDN translocation (ML-2 cell line, *_ML2, and an ex vivo PDX-derived primary sample, _PDX) or the t(8;21) RUNX1::RUNX1T1 translocation (Kasumi-1 cell line, _KASU), following 48 h treatment with 2 uM arsenic trioxide (_TREATED) or vehicle control (_UNTREATED). Samples were analyzed by label-free DIA-PASEF LC-MS/MS in technical triplicate, indicated by the suffixes *1, 2 and 3, corresponding to the three technical injections of each biological sample. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-07-27 |
| AnnouncementXML | Submission_2026-07-27_05:59:35.115.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Claudia Tregnago |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Acetyl; Oxidation; Carbamidomethyl |
| Instrument | timsTOF fleX |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-07-24 03:18:14 | ID requested | |
| ⏵ 1 | 2026-07-27 05:59:35 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: DatasetType:Proteomics, acute myeloid leukemia, AML, mass spectrometry, arsenic trioxide, ATO, KMT2A::AF6, RUNX1::RUNX1T1, ML-2, Kasumi-1, nuclear protein extract, proteomics |
Contact List
| Claudia Tregnago, PhD | |
|---|---|
| contact affiliation | University of Padova |
| contact email | claudia.tregnago@unipd.it |
| lab head | |
| Claudia Tregnago | |
| contact affiliation | University of Padova |
| contact email | claudia.tregnago@unipd.it |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v14/MSV000102584/ |
