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PXD081421-1
PXD081421 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic analysis reveals the regulatory effect of octanoic acid on tumor protein expression profiling in colorectal cancer liver metastasis |
| Description | Colorectal cancer liver metastasis (CRCLM) is the primary cause of poor prognosis and mortality in patients with colorectal cancer (CRC). Aberrant protein expression and dysregulated signaling networks in tumor tissues are key drivers of CRCLM malignant proliferation and metastasis. As a crucial medium-chain fatty acid, octanoic acid exhibits potential regulatory effects on tumor biological behaviors and microenvironmental homeostasis. However, the systematic protein-level mechanism by which octanoic acid modulates CRCLM progression remains unclear. In this study, a well-established CRCLM mouse model was treated with octanoic acid intervention, and tumor tissues of liver metastatic lesions were collected for quantitative proteomic analysis. Differentially expressed proteins (deps) between the octanoic acid-treated group and the control group were screened, followed by functional enrichment analysis including gene ontology (GO) and kyoto encyclopedia of genes and genomes (KEGG) pathways to identify core regulatory proteins and key signaling pathways. |
| HostingRepository | iProX |
| AnnounceDate | 2026-07-20 |
| AnnouncementXML | Submission_2026-07-21_18:14:34.960.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Banglun Pan |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-07-21 18:06:56 | ID requested | |
| ⏵ 1 | 2026-07-21 18:14:35 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Octanoic acid, colorectal cancer liver metastasis |
Contact List
| Zengbin Wang | |
|---|---|
| contact affiliation | Fujian Medical University |
| contact email | 18232112250@163.com |
| lab head | |
| Banglun Pan | |
| contact affiliation | Fujian Medical University |
| contact email | 1335563838@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
