PXD081324-1

PXD081324 is an original dataset announced via ProteomeXchange.

Title	Proteomic profiling of intermittent parathyroid hormone-preconditioned BMSC-derived exosomes
Description	This project investigates the proteomic alterations induced by intermittent parathyroid hormone preconditioning in exosomes derived from rat bone marrow mesenchymal stem cells. Exosomes were collected from untreated BMSCs (EXO), BMSCs subjected to continuous PTH stimulation (cEXO), and BMSCs subjected to intermittent PTH stimulation (iEXO). Three biological replicates per group were analyzed using label-free data-independent acquisition LC-MS/MS. Comparative proteomic analysis was performed to characterize the molecular signatures associated with intermittent PTH preconditioning and their potential roles in osteogenesis and bone regeneration.
HostingRepository	iProX
AnnounceDate	2026-07-18
AnnouncementXML	Submission_2026-07-20_00:40:59.795.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiaqi Fang
SpeciesList	scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Astral

Revision	Datetime	Status	ChangeLog Entry
0	2026-07-20 00:39:06	ID requested
⏵ 1	2026-07-20 00:41:00	announced

Dataset with its publication pending

submitter keyword: exosome, extracellular vesicle, intermittent parathyroid hormone, iPTH, bone marrow mesenchymal stem cell, BMSC, DIA proteomics, Orbitrap Astral, bone regeneration

Zezhu Zhou
contact affiliation	Shanghai Tenth People's Hospital, School of Medicine, Tongji University
contact email	drzhouzezhu@163.com
lab head
Jiaqi Fang
contact affiliation	Shanghai Tenth People's Hospital, School of Medicine, Tongji University
contact email	2133293@tongji.edu.cn
dataset submitter

iProX dataset URI