PXD081317-1

PXD081317 is an original dataset announced via ProteomeXchange.

Title	Compartment-Specific B-Cell Glycosylation Remodeling Links Inflammatory Signaling to Pathogenic Fc Glycoforms in NMDAR Encephalitis
Description	our study provides an integrated multi-omics characterization of compartment-specific B-cell N-glycosylation remodeling in anti-NMDAR encephalitis. By combining CSF IgG glycoproteomics with paired single-cell transcriptomics, we identify a coordinated transcriptional reprogramming associated with inflammatory microenvironmental signaling, B-cell differentiation, and altered Fc glycan composition. Importantly, our findings support a model in which increasing antibody biosynthetic demand progressively exceeds the relative capacity for terminal glycan processing during plasma-cell activation, providing a plausible explanation for the discordance between glycosyltransferase transcription and the under-sialylated IgG phenotype observed in poor outcome groups.
HostingRepository	iProX
AnnounceDate	2026-07-18
AnnouncementXML	Submission_2026-07-20_00:23:53.580.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yong Zhang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	deaminated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2026-07-20 00:23:32	ID requested
⏵ 1	2026-07-20 00:23:54	announced

Dataset with its publication pending

submitter keyword: NMDAR, IgG, glycosylation

Yong Zhang
contact affiliation	West China Hospital, Sichuan University
contact email	nankai1989@foxmail.com
lab head
Yong Zhang
contact affiliation	West China Hospital, Sichuan University
contact email	nankai1989@foxmail.com
dataset submitter

iProX dataset URI