⮝ Full datasets listing
PXD081227-1
PXD081227 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Hippophae rhamnoides-Derived Exosome-like Nanovesicles Alleviate Dexamethasone-Induced Sarcopenia by Remodeling Skeletal Muscle Lipid Metabolism |
| Description | Skeletal muscle atrophy driven by glucocorticoid excess is a clinically relevant contributor to sarcopenia, yet safe and biologically integrated interventions remain limited. Here we report that extracellular exosome-like nanovesicles derived from Hippophae rhamnoides fruits (HR-ELNs) protect against dexamethasone-induced muscle wasting. HR-ELNs isolated by sucrose density gradient ultracentrifugation exhibited nanoscale vesicular morphology and carried a metabolite-rich cargo. In C2C12 cells, HR-ELNs were rapidly internalized and localized predominantly in the cytoplasm, where they counteracted dexamethasone-induced upregulation of Atrogin-1 and MuRF1, downregulation of MyoG, and reduction of MyHC-positive myotube area. In a dexamethasone-induced sarcopenia mouse model, intramuscular HR-ELN administration improved grip strength and treadmill endurance while attenuating the increase in body fat content. Multi-omics profiling of skeletal muscle revealed coordinated transcriptomic and proteomic remodeling after HR-ELN treatment, with convergent enrichment of lipid metabolism, fatty acid degradation, AMPK signaling and PPAR-related pathways. Histological analyses further supported reduced lipid deposition and altered PPAR immunoreactivity in gastrocnemius muscle. Together, these findings identify HR-ELNs as bioactive plant-derived nanovesicles that couple anti-atrophic and metabolic effects, and suggest a natural nanotherapeutic strategy for glucocorticoid-associated skeletal muscle dysfunction. |
| HostingRepository | iProX |
| AnnounceDate | 2026-07-16 |
| AnnouncementXML | Submission_2026-07-16_20:02:31.228.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Qingrun Zhu |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-07-16 20:02:16 | ID requested | |
| ⏵ 1 | 2026-07-16 20:02:31 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: sarcopenia, plant-derived exosome-like nanovesicles, dexamethasone, PPAR signaling |
Contact List
| Dachuan Wang | |
|---|---|
| contact affiliation | The Second Qilu Hospital of Shandong University |
| contact email | wangdachuan@medmail.com.cn |
| lab head | |
| Qingrun Zhu | |
| contact affiliation | The Second Qilu Hospital of Shandong University |
| contact email | zhuqingrun@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
