PXD080883 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Human gastric cardia adenocarcinoma LC-MSMS |
| Description | Therapeutic targets for gastric cardia adenocarcinoma (GCA), particularly for HER2-negative patients, are lacking. Here, we conducted multi-omics profiling on 128 GCA patients using Mass spectrometry, whole-exome sequencing, RNA-Seq, scRNA-Seq and spatial transcriptomics. Based on HER2 expression levels, we categorized patients into HER2-high, - low, and -negative groups and confirmed the favorable prognostic significance of HER2. We uncovered an enrichment of DNA repair features in the HER2-high group, while HER2-low and -negative groups exhibited strong inflammation. We found that tumor mutation burden may not be the distinguishing factor among these three groups. We revealed that the HER2- negative and -low groups have a tumor-suppressive immune microenvironment. Our study revealed that anti-inflammatory approaches and immune checkpoint inhibition targeting the CD47/SIRPA axis may serve as therapeutic strategies for patients with HER2-negative GCA. These findings highlight promising avenues for personalized treatment of GCA. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-12 |
| AnnouncementXML | Submission_2026-07-12_02:21:12.764.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Li Dong Wang |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-07-11 06:20:45 | ID requested | |
| ⏵ 1 | 2026-07-12 02:21:13 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Human gastric cardia adenocarcinoma tumor and its normal adjacent tissues LC-MSMS |
Contact List
| Li Dong Wang |
|---|
| contact affiliation | State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key 7 Laboratory for Esophageal Cancer Research of the First Affiliated Hospital, Zhengzhou 8 University, Zhengzhou 450052, China. |
| contact email | ldwang2007@126.com |
| lab head | |
| Li Dong Wang |
|---|
| contact affiliation | The First Affiliated Hospital of Zhengzhou University |
| contact email | ldwang2007@126.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD080883 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD080883
- Label: PRIDE project
- Name: Human gastric cardia adenocarcinoma LC-MSMS
