PXD080706-1

PXD080706 is an original dataset announced via ProteomeXchange.

Title	MHC-I immunopeptidome profiling of macrophage-derived antigen depots (MAtigens)
Description	This project presents the comprehensive MHC-I immunopeptidomic profiling of macrophage-derived antigen depots (MAtigens) to demonstrate their capability for antigen enrichment and the generation of a biologically optimized antigen repertoire. To validate this cross-species, mass spectrometry-based proteomics was performed on two distinct experimental sets. The murine cohort comprises unmodified macrophages (M), murine tumor cells (BO), and their corresponding engineered MAtigens (M@BO). The human clinical cohort includes human macrophages (M), patient-derived tumor cells (PDC, specifically pancreatic ductal adenocarcinoma), and the resulting human MAtigens (M@PDC). By identifying and comparing the presented MHC-I peptides across these groups, this dataset provides critical evidence that the MAtigen platform effectively internalizes and optimizes tumor-specific antigens for enhanced presentation.
HostingRepository	iProX
AnnounceDate	2026-07-07
AnnouncementXML	Submission_2026-07-07_23:55:40.428.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jianxin Wang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606; scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2026-07-07 23:55:07	ID requested
⏵ 1	2026-07-07 23:55:40	announced

Dataset with its publication pending

submitter keyword: Immunopeptidomics, MHC-I, Macrophage, MAtigen, Antigen presentation, Neoantigen, Cancer vaccine, Mass spectrometry

Jianxin Wang
contact affiliation	Fudan University
contact email	jxwang@fudan.edu.cn
lab head
Jianxin Wang
contact affiliation	Fudan University
contact email	jxwang@fudan.edu.cn
dataset submitter

iProX dataset URI