⮝ Full datasets listing
PXD080650-1
PXD080650 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Discovery of Selective and Potent BRPF1 Dege-reraders for the Treatment of Endocrine-sensitive Breast Cancer |
| Description | ESR1 mutations and activation of growth factor signaling (e.g., PI3K-AKT) drive endocrine therapy resistance in breast cancer, largely limiting the success of breast cancer treatment. We reported a first-in-class, selective and potent BRPF1-targeted proteolysis-targeting chimera (PROTAC) B-8, and it downregulated H3K23ac and ER, causing cell cycle arrest and autophagic cell death. |
| HostingRepository | iProX |
| AnnounceDate | 2026-07-06 |
| AnnouncementXML | Submission_2026-07-07_00:06:40.686.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Qiheng Zhao |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-07-07 00:06:23 | ID requested | |
| ⏵ 1 | 2026-07-07 00:06:41 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: BRPF1, Breast Cancer, Degraders |
Contact List
| Yubo Zhou | |
|---|---|
| contact affiliation | Zhongshan Institute for Drug Discovery |
| contact email | ybzhou@simm.ac.cn |
| lab head | |
| Qiheng Zhao | |
| contact affiliation | Nanjing University of Chinese Medicine |
| contact email | zhaoqiheng323@zidd.ac.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
