⮝ Full datasets listing
PXD080569-1
PXD080569 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Sialic Acid Linkage-Specific Alkylamidation-Based Method for Comprehensive N- and O-Glycoproteomic Profiling of Human Plasma |
| Description | Sialic acids are attached to glycoproteins via alpha2,3- or alpha2,6-linkages and play important roles in disease pathogenesis. Sialyl linkage-specific derivatization of intact N- and/or O-glycopeptides remains challenging because of the diverse reactive functional groups within peptides. In this report, we present a comprehensive workflow for identifying and quantifying sialylated N- and O-glycopeptides that integrates dimethyl labeling for amino-group blocking, sialic acid linkage-specific alkylamidation, and label-free quantification. |
| HostingRepository | jPOST |
| AnnounceDate | 2026-06-10 |
| AnnouncementXML | Submission_2026-07-09_17:27:43.671.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hiroki Tsumoto |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide; alpha-amino dimethylated residue; N6,N6-dimethyl-L-lysine; unknown modification; unknown modification; Asp->Asn |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-07-05 16:21:07 | ID requested | |
| ⏵ 1 | 2026-07-09 17:27:44 | announced |
Publication List
| Tsumoto H, Nishikaze T, Sekiya S, Umezawa K, Kawakami K, Masui Y, Ikebe K, Kamide K, Hirata T, Gondo Y, Iwamoto S, Tanaka K, Miura Y, -Glycoproteomic Profiling of Human Plasma. Anal Chem, 98(28):20863-20876(2026) [pubmed] |
Keyword List
| submitter keyword: Sialic Acid Linkage-Specific Alkylamidation, SALSA, N-Glycoproteomic, O-Glycoproteomic, Human plasma |
Contact List
| Yuri Miura | |
|---|---|
| lab head | |
| Hiroki Tsumoto | |
| contact affiliation | Tokyo Metropolitan Institute for Geriatrics and Gerontology |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST004735/ |
