⮝ Full datasets listing
PXD080385-1
PXD080385 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic Dynamics Reveal Cell-Cycle and Rho GTPase Remodeling Underlying Senescence-Associated Traits in Human Chondrocytes during Sustained IL-1beta Signaling |
| Description | Chronic inflammatory signaling contributes to cartilage degeneration across multiple joint diseases, yet the molecular consequences of sustained cytokine exposure remain incompletely understood. We investigated how prolonged interleukin-1beta (IL-1beta) stimulation remodels the chondrocyte proteome over time and whether these changes are associated with senescence-associated traits. Primary human articular chondrocytes were exposed to sustained IL-1beta stimulation (10 ng/mL) for up to four days. Time-resolved data-independent acquisition (DIA) proteomics was combined with immunofluorescence, quantitative PCR, multiplex metalloproteinase profiling, BrdU incorporation assays, growth-curve analysis, and senescence-associated beta-galactosidase measurements. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-06-30 |
| AnnouncementXML | Submission_2026-06-30_13:19:02.931.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | hellen |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 240 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-06-30 11:10:44 | ID requested | |
| ⏵ 1 | 2026-06-30 13:19:03 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: chondrocyte, IL1-BETA, time-course, DIA, DatasetType:Proteomics |
Contact List
| Ana Marisa Chudzinski-Tavassi | |
|---|---|
| contact affiliation | Butantan Institute |
| contact email | ana.chudzinski@butantan.gov.br |
| lab head | |
| hellen | |
| contact affiliation | usp |
| contact email | hellen.valerio@usp.br |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v13/MSV000102314/ |
