PXD080372-1

PXD080372 is an original dataset announced via ProteomeXchange.

Title	SUV39H1/2-mediated H3K9me3 restricts ERV-induced immune response in Acute Myeloid Leukemia cells
Description	Acute myeloid leukemia (AML) is a malignant disorder of hematopoietic stem cells (HSPCs) where normal 3D genome architectures are essential for proper lineage-specific functions. Repressive epigenetic features, such as Histone 3 Lysine 9 trimethylation (H3K9me3), play vital roles in maintaining healthy HSPCs, but we still understand very little about their roles in promoting AML. Marking constitutive heterochromatin, H3K9me3 is deposited by methyltransferases and participates in heterochromatin condensation; however, its significance in myeloid 3D genome architecture remains unclear. I identified SUV39H1, a key H3K9-specific methyltransferase, as a major depositor in AML cells, essential for sustaining proliferation and myeloid differentiation gene signatures. Moreover, in AML cells treated with DNA hypomethylating agents (HMAs), alterations in H3K9me3 distribution are observed. This suggests a potential role of SUV39H1, the major H3K9me3 depositor, in heterochromatin reorganization in the context of DNA hypomethylation.
HostingRepository	PRIDE
AnnounceDate	2026-06-30
AnnouncementXML	Submission_2026-06-30_07:19:40.755.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Josiah Hiu-yuen Wong
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	TSQ Altis

Revision	Datetime	Status	ChangeLog Entry
0	2026-06-30 05:49:33	ID requested
⏵ 1	2026-06-30 07:19:41	announced

Dataset with its publication pending

submitter keyword: Human, AML

Feng Yue
contact affiliation	Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA
contact email	yue@northwestern.edu
lab head
Josiah Hiu-yuen Wong
contact affiliation	Northwestern University
contact email	josiah.wong@northwestern.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD080372

PRIDE project URI

• PRIDE
  1. PXD080372
     1. Label: PRIDE project
     2. Name: SUV39H1/2-mediated H3K9me3 restricts ERV-induced immune response in Acute Myeloid Leukemia cells