⮝ Full datasets listing
PXD080343-1
PXD080343 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Lrrc71 stabilizes septin4 to ensure sperm annulus integrity and male fertility |
| Description | Lrrc71 disruption resulted in male infertility involving mitochondrial sheath and sperm annulus damage. Lrrc71 could directly bind to Septin4 through its N-terminal. Mechanistically, Lrrc71 stabilizes the sperm annulus by preventing the autophagy pathway degradation of Septin4. Collectively, our findings demonstrate that Lrrc71 serves as a central hub regulating sperm motility and annulus integrity, providing insights into the pathogenic mechanisms of infertility caused by human Lrrc71 mutations. |
| HostingRepository | iProX |
| AnnounceDate | 2026-06-29 |
| AnnouncementXML | Submission_2026-06-29_20:27:11.269.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jinmei Cheng |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-06-29 20:26:42 | ID requested | |
| ⏵ 1 | 2026-06-29 20:27:11 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Lrrc71, Septin4, sperm annulus, male fertility |
Contact List
| Jinmei Cheng | |
|---|---|
| contact affiliation | Nantong University |
| contact email | chengjinmei@ntu.edu.cn |
| lab head | |
| Jinmei Cheng | |
| contact affiliation | Nantong University |
| contact email | chengjinmei@ntu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
