PXD080148-1

PXD080148 is an original dataset announced via ProteomeXchange.

Title	Proteomic profiling of xenobiotic and nutrient transporters in human placenta of different gestational ages
Description	The placenta serves a critical role in nutrient uptake and waste elimination for the developing fetus and is responsible for the uptake and/or exchange of xenobiotics, including medications, between the maternal and fetal bloodstreams. Very little is understood about fetal drug and nutrient exposure during pregnancy and how it may change over the course of fetal development. The primary goal of this work was to profile the abundance of placental xenobiotic and nutrient transporters over the course of gestation using a data-independent analysis (DIA) proteomics approach. Building a deeper understanding of these proteins at the interface between the fetal and maternal bloodstreams will inform future studies designed to address questions regarding the safety and efficacy of therapeutics and nutrient supplements used during pregnancy. A total of 139 solute carrier (SLC) and ATP-cassette binding (ABC) transport proteins were identified across all samples, 80 of which were found in every sample (n = 34). Seventeen transport proteins (14 SLC, 3 ABC) were found to be significantly altered between trimesters during development. To the best of our knowledge, this study represents the first global proteomic characterization of placental membrane-associated proteins using DIA-MS proteomics and lays the groundwork for further advancements in the understanding of the membrane-associated proteome during fetal development.
HostingRepository	PanoramaPublic
AnnounceDate	2026-06-25
AnnouncementXML	Submission_2026-06-25_09:05:01.081.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Eric Weaver
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	Carbamidomethyl
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2026-06-24 23:41:35	ID requested
⏵ 1	2026-06-25 09:05:01	announced

no publication

submitter keyword: Proteomics, Mass spectrometry, Transporters, Nutrients, Xenobiotics, Placenta, Gestation

Sam Arnold
contact affiliation	University of Washington, Department of Pharmaceutics
contact email	slarnold@uw.edu
lab head
Eric Weaver
contact affiliation	University of Washington, Department of Pharmaceutics
contact email	ericw04@uw.edu
dataset submitter

Panorama Public dataset URI