⮝ Full datasets listing
PXD080015-1
PXD080015 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteome Mapping of Formaldehyde-derived Modifications and Cross-links by Real-time Isotopic Signature Targeted Profiling |
| Description | We developed a chemoproteomics strategy which combines the real-time isotopic-signature-targeted profiling ("isoSTAR") platform with isotopically labeled FAs to perform a global and site‑specific profiling of FA‑derived modifications in cellular and tissue proteomes. Three distinct masses associated with FA modifications on lysines were detected through the real-time targeted profiling and the open-search strategy. By combining multiple chemical proteomic strategies, we mapped the lysine modifications by formaldehyde and elucidated their biological functions. We also established a novel real-time targeted profiling method for identifying formaldehyde cross-linked peptides, and leveraged its small size and high permeability to enable the application of CXMS in tissue samples. These findings significantly advance our understanding of formaldehyde’s molecular roles in biological systems. |
| HostingRepository | iProX |
| AnnounceDate | 2026-06-22 |
| AnnouncementXML | Submission_2026-06-22_20:11:05.968.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Tianyu Feng |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-06-22 20:10:38 | ID requested | |
| ⏵ 1 | 2026-06-22 20:11:06 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Formaldehyde, Post-translational modifications, Isotopic envelope, Real-time targeted profiling, Chemical crosslinking mass spectrometry. |
Contact List
| Chu Wang | |
|---|---|
| contact affiliation | Peking University |
| contact email | chuwang@pku.edu.cn |
| lab head | |
| Tianyu Feng | |
| contact affiliation | Peking University |
| contact email | 787712784@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
