PXD080006 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | An integrated proteome and phospho-proteome approach to study BPA toxicity on placenta. |
| Description | The environmental exposure of various Endocrine disrupting chemicals (EDCs) like Bisphenol-A (BPA), can affect human health by inducing hormonal imbalance important for physiological homeostasis. Pregnant females are more susceptible for BPA mediated toxicity. BPA can reach maternal circulation by ingestion, inhalation or dermal contact from plastic goods or everyday house-hold items, which then crosses the placental barrier and imparts damage on trophoblast cells. This BPA mediated cellular injury directly alters feto-maternal homeostasis disrupting fetal development and growth. The feto-maternal disruption is induced by impaired cellular signaling in placenta, which can also affect the post translational protein phosphorylation patterns. Therefore, this study explores the dynamic proteome change upon BPA exposure which also affects the kinase associated phospho-signatures in both early trimester trophoblast cells and murine placenta. This finding provides an important insight on the mechanism of altered phosphorylation which may drive the BPA associated toxicity in placenta and trophoblast cells contributing towards placenta mediated reproductive disorders. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-14 |
| AnnouncementXML | Submission_2026-07-14_04:20:44.336.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | TUSHAR KANTI MAITI |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | phosphorylated residue |
| Instrument | ZenoTOF 7600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-06-22 14:22:12 | ID requested | |
| ⏵ 1 | 2026-07-14 04:20:44 | announced | |
Publication List
Keyword List
| submitter keyword: Bisphenol-A,Placenta, Extra-villous trophoblast, HR-MRM, Targeted proteomics, Ecotoxico-proteomics |
Contact List
| Tushar Kanti Maiti |
|---|
| contact affiliation | Professor Regional Centre for Biotechnology NCR Biotech Science Cluster 3rd Milestone, Faridabad-Gurgaon Expressway Faridabad-121001, Haryana INDIA |
| contact email | tkmaiti@rcb.res.in |
| lab head | |
| TUSHAR KANTI MAITI |
|---|
| contact affiliation | Regional Centre for Biotechnology |
| contact email | tkmaiti@rcb.res.in |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD080006 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD080006
- Label: PRIDE project
- Name: An integrated proteome and phospho-proteome approach to study BPA toxicity on placenta.
