PXD079878-1

PXD079878 is an original dataset announced via ProteomeXchange.

Title	p-tau217-IP from muscle to determine BD-tau and big tau isoforms
Description	Blood p-tau217 has emerged as an accurate biomarker of Alzheimer’s disease (AD) pathology but is also elevated in amyotrophic lateral sclerosis (ALS), likely reflecting confounding contributions from peripheral tau released from denervated muscle fibres. Thus, assays selectively measuring brain-derived (BD) tau and BD-p-tau217 may improve diagnostic specificity. Targeted mass spectrometry after p-tau217 immunoprecipitation was applied to investigate the presence of CNS tau isoforms (BD-tau without exon 4a) and big tau*isoforms (including exon4a) in muscle tissue.
HostingRepository	PRIDE
AnnounceDate	2026-09-04
AnnouncementXML	Submission_2026-09-04_01:47:19.499.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Henning Großkopf
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2026-06-18 06:24:17	ID requested
⏵ 1	2026-09-04 01:47:20	announced

Dataset with its publication pending

submitter keyword: LC-MS/MS, PRM, ALS, tau

Prof. Dr. Markus Otto
contact affiliation	Department of Neurology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
contact email	Markus.Otto@uk-halle.de
lab head
Henning Großkopf
contact affiliation	Department of Neurology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
contact email	henning.grosskopf@uk-halle.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD079878

PRIDE project URI

• PRIDE
  1. PXD079878
     1. Label: PRIDE project
     2. Name: p-tau217-IP from muscle to determine BD-tau and big tau isoforms