⮝ Full datasets listing
PXD079723-1
PXD079723 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Quorum sensing rewires membrane vesicle protein cargo to promote antibiotic persistence in Streptococcus mutans |
| Description | The CSP-ComDE quorum-sensing (QS) system of Streptococcus mutans, a human oral pathogen, is recognized as a central regulator of general stress responses and population survival strategies. Extracellular membrane vesicles are nanoscale lipid bilayer structures carrying a diverse cargo of biomolecules and implicated in a broad range of biological processes. Importantly, vesicle biogenesis and cargo composition are highly regulated processes, shaped by the physiological state of the cells and their surrounding environment. In the present study, we investigated the impact of the CSP?ComDE QS system on vesicle biogenesis and protein cargo composition in S. mutans. S. mutans planktonic cells were cultivated in the absence and in the presence of the CSP pheromone (to mimic an environmental stress condition), and membrane vesicles were isolated at stationary growth phase. Membrane vesicle proteomic analysis was then performed to compare the protein cargo of membrane vesicles isolated from non-induced cultures and membrane vesicles isolated from CSP-induced cultures. The data obtained contribute to the understanding of the role of the CSP-ComDE QS system in membrane vesicle biogenesis and cargo composition in S. mutans. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-06-19 |
| AnnouncementXML | Submission_2026-06-19_14:19:21.414.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Inga Kireeva |
| SpeciesList | scientific name: Streptococcus mutans UA159; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | instrument model |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-06-15 13:10:54 | ID requested | |
| ⏵ 1 | 2026-06-19 14:19:21 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: mass spectrometry, LC/MS/MS, membrane vesicles, proteomics analysis, Streptococcus mutans, DatasetType:Proteomics |
Contact List
| Celine Levesque | |
|---|---|
| contact affiliation | University of Toronto |
| contact email | celine.levesque@dentistry.utoronto.ca |
| lab head | |
| Inga Kireeva | |
| contact affiliation | CAGEF UofT |
| contact email | inga.kireeva@utoronto.ca |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v13/MSV000102160/ |
