PXD079487-1

PXD079487 is an original dataset announced via ProteomeXchange.

Title	Multi-omics Study of Breast Cancer Initiation and Progression Across the Disease Continuum
Description	This project is based on multi-stage disease samples obtained from the same patient with breast invasive ductal carcinoma and innovatively proposes a “space-for-time substitution” research strategy. Under a shared genetic background, we reconstruct the continuous evolutionary trajectory from normal mammary ducts through ductal hyperplasia and ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC), thereby overcoming the limitations of conventional approaches that infer disease progression by integrating samples from different individuals at different stages. In addition, we will establish a “super-omics” framework that integrates single-cell spatial proteomics, single-cell spatial transcriptomics, and nineteen large-scale omics modalities, enabling a comprehensive and multidimensional characterization of breast cancer evolution.
HostingRepository	iProX
AnnounceDate	2026-06-09
AnnouncementXML	Submission_2026-06-09_18:48:32.397.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Feiyang Ji
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF HT

Revision	Datetime	Status	ChangeLog Entry
0	2026-06-09 18:48:12	ID requested
⏵ 1	2026-06-09 18:48:32	announced

Dataset with its publication pending

submitter keyword: Breast Cancer

Feiyang Ji
contact affiliation	Zhejiang University
contact email	feiyangji@zju.edu.cn
lab head
Feiyang Ji
contact affiliation	Zhejiang University
contact email	feiyangji@zju.edu.cn
dataset submitter

iProX dataset URI