PXD079442-1

PXD079442 is an original dataset announced via ProteomeXchange.

Title	Fructose directly remodels the TOM complex to impair oxidative phosphorylation in podocytes
Description	This study demonstrated that, in addition to the known metabolic effects of fructose, excessive fructose directly binds to the translocase of the outer membrane (TOM) complex via non-covalent interaction with TOM22, inducing subtle but functionally critical conformational changes in the TOM complex. These changes markedly inhibit the transport of mitochondrial ribosome subunits, impair mitochondrial protein translation, and disrupt oxidative phosphorylation, independent of fructose metabolism. Using both fructose-exposed podocytes and mouse glomerular injury models, the authors further showed that disrupting the fructose-TOM22 interaction restores mitochondrial ribosome subunit trafficking and prevents mitochondrial and oxidative phosphorylation dysfunction, thereby revealing a previously unrecognized, metabolism-independent pathogenic mechanism by which fructose directly remodels a mitochondrial protein complex to drive mitochondrial dysfunction.
HostingRepository	iProX
AnnounceDate	2026-06-09
AnnouncementXML	Submission_2026-06-09_02:15:36.584.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nannan Wang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	ZenoTOF 7600

Revision	Datetime	Status	ChangeLog Entry
0	2026-06-09 02:15:18	ID requested
⏵ 1	2026-06-09 02:15:37	announced

Dataset with its publication pending

submitter keyword: Fructose TOM complex oxidative phosphorylation podocytes

Lei Fang
contact affiliation	Nanjing University
contact email	njfanglei@nju.edu.cn
lab head
Nannan Wang
contact affiliation	Nanjing University
contact email	602023350023@smail.nju.edu.cn
dataset submitter

iProX dataset URI