PXD079259-1

PXD079259 is an original dataset announced via ProteomeXchange.

Title	Loss of ULK1 Promotes TLR4 Acetylation in THP-1 Macrophages
Description	This study focuses on the regulatory effect of ULK1 (Unc-51-like autophagy activating kinase 1) deficiency on TLR4 (Toll-like receptor 4) acetylation in THP-1 cells. ULK1, a key kinase involved in autophagy initiation, has been reported to participate in the regulation of various cellular processes, including inflammation and signal transduction. TLR4, a crucial pattern recognition receptor, plays a vital role in recognizing pathogen-associated molecular patterns and initiating innate immune responses, and its acetylation modification is closely related to the activation of downstream signaling pathways. In this study, ULK1-deficient THP-1 cells were constructed, and the acetylation level of TLR4 in the cells was detected by IP-MS methods. The results showed that the deficiency of ULK1 significantly promoted the acetylation of TLR4 in THP-1 cells, suggesting that ULK1 may act as a negative regulator of TLR4 acetylation.
HostingRepository	iProX
AnnounceDate	2026-06-04
AnnouncementXML	Submission_2026-06-04_00:59:38.731.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yafei Chang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	acetylated residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2026-06-04 00:59:24	ID requested
⏵ 1	2026-06-04 00:59:39	announced

Dataset with its publication pending

submitter keyword: ULK1, TLR4, acetylation, macrophage

Sijia Liang
contact affiliation	Sun Yat-sen University
contact email	liangsj5@mail.sysu.edu.cn
lab head
Yafei Chang
contact affiliation	Sun Yat-sen University
contact email	changyf5@mail.sysu.edu.en
dataset submitter

iProX dataset URI