⮝ Full datasets listing
PXD079249-1
PXD079249 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Temporal Multi-Omic Analysis Uncovers Sex-Biased Molecular Programs Underlying Skeletal Muscle Adaptation to Endurance Training, Findings from MoTrPAC |
| Description | This proteomics dataset focuses on the study of changes in protein oxidation and acetylation in gastrocnemius muscle. The dataset is a subset of an endurance exercise training study that targets young adult (6-month-old) rats. Specifically, male and female Fischer 344 rats (n = 12) were subjected to progressive treadmill endurance exercise training for 1, 2, 4, or 8 weeks, with tissues collected 48 hours after the last exercise bout. Sex-matched sedentary, untrained rats were used as controls. This study contributes to MoTrPAC's broader mission, which is to identify molecular changes occurring due to exercise. The ultimate goal is to understand how physical activity can improve and sustain health across various ages and fitness levels. The program is supported by the NIH Common Fund. For additional information, visit the MoTrPAC Data Hub at https://motrpac-data.org/. [doi:10.25345/C5R78603Q] [dataset license: CC0 1.0 Universal (CC0 1.0)] |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-06-24 |
| AnnouncementXML | Submission_2026-06-24_19:34:00.813.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Matthew Monroe |
| SpeciesList | scientific name: Rattus norvegicus; common name: Norway rat; NCBI TaxID: 10116; |
| ModificationList | Oxidation; Carbamidomethyl; Nethylmaleimide; Deamidated; TMT6plex; TMTpro |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-06-03 19:30:38 | ID requested | |
| ⏵ 1 | 2026-06-24 19:34:05 | announced |
Publication List
| Many GM, Jin C, Day N, Iyer G, Smith G, Sanford J, Bareja A, Jimenez-Morales D, Voos K, Leach D, Sagendorf T, Li X, Gaffrey M, Attah I, Mitchell H, Viggars M, Gaul D, Huffman KM, F, é, rnandez F, Snyder MP, Ortlund E, Kohrt W, Wheeler MT, Kraus WE, Esser KA, Goodpaster B, Burant CF, Newgard CB, Hevener A, Bodine SC, Qian WJ, Schenk S, Adkins J, Lindholm ME, Temporal Multi-Omic Analysis Uncovers Sex-Biased Molecular Programs Underlying Skeletal Muscle Adaptation to Endurance Training. bioRxiv, ():(2025) [pubmed] |
Keyword List
| submitter keyword: PTMs, endurance exercise, redox, MoTrPAC, gastrocnemius, 6 months old, DatasetType:Proteomics |
Contact List
| Wei-Jun Qian | |
|---|---|
| contact affiliation | Pacific Northwest National Laboratory |
| contact email | Weijun.Qian@pnnl.gov |
| lab head | |
| Joshua N. Adkins | |
| contact affiliation | Pacific Northwest National Laboratory |
| contact email | Joshua.Adkins@pnnl.gov |
| lab head | |
| Matthew Monroe | |
| contact affiliation | Pacific Northwest National Laboratory |
| contact email | matthew.monroe@pnnl.gov |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v13/MSV000102039/ |
