⮝ Full datasets listing
PXD079163-1
PXD079163 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | A MLKL inhibitor suppresses liver fibrosis by regulating hepatocyte death and macrophage inflammation |
| Description | Here, using CCl₄-induced liver injury models in mice and complementary in vitro cellular models, we found that MLKL deficiency reduced hepatocyte death and inflammatory responses in hepatic immune cells, thereby reducing collagen deposition and liver fibrosis. Mechanistically, MLKL deficiency attenuated hepatic inflammatory responses by reducing DAMPs release, preventing intracellular potassium depletion, and suppressing activation of the TLR–JNK signaling pathway. |
| HostingRepository | iProX |
| AnnounceDate | 2026-06-02 |
| AnnouncementXML | Submission_2026-06-01_20:06:58.265.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jingbo Qie |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-06-01 20:06:40 | ID requested | |
| ⏵ 1 | 2026-06-01 20:06:58 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Liver Fibrosis, MLKL, Macrophage Inflammation, Cell death, Channel Function |
Contact List
| Jingbo Qie | |
|---|---|
| contact affiliation | Fudan University |
| contact email | jingboqei@fudan.edu.cn |
| lab head | |
| Jingbo Qie | |
| contact affiliation | Fudan University |
| contact email | jingboqie@fudan.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
