PXD079016 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Acute proteome responses to de novo sphingolipid synthesis inhibition suggest cancer combination therapies |
| Description | Sphingolipids are essential structural and signaling lipids that support membrane integrity and govern cell fate decisions. Whereas the consequences of chronic sphingolipid inhibition have been extensively explored, the immediate cellular responses to reduced sphingolipid levels remain poorly defined. Here, we performed mass spectrometry analysis of subcellular fractions to examine proteome alterations 4 hours after myriocin treatment, which inhibits de novo sphingolipid synthesis. We have identified changes in the abundance of 1307 proteins across the membrane, cytosolic, and nuclear fractions. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-08 |
| AnnouncementXML | Submission_2026-06-08_12:15:44.342.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zhiping Wu |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-05-28 13:28:47 | ID requested | |
| ⏵ 1 | 2026-06-08 12:15:44 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: cancer, myriocin, proteome,De novo sphingolipid synthesis |
Contact List
| Junmin Peng |
|---|
| contact affiliation | St. Jude Children's Research Hospital |
| contact email | junmin.peng@stjude.org |
| lab head | |
| Zhiping Wu |
|---|
| contact affiliation | St. Jude Children's Research Hospital |
| contact email | zhiping.wu@stjude.org |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD079016 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD079016
- Label: PRIDE project
- Name: Acute proteome responses to de novo sphingolipid synthesis inhibition suggest cancer combination therapies
