PXD078825 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Label-Free Quantitative Proteomics of Stallion Seminal Plasma Reveals Oxidative Stress–Associated Protein Signatures Linked to Sperm Motility and Viability |
| Description | Seminal plasma proteins play critical roles in sperm function, motility, viability and oxidative stress regulation in stallions. In this study, label-free quantitative (LFQ) proteomics was applied to characterize seminal plasma protein signatures associated with sperm quality in Arabian stallions. Semen samples were classified into High-CASA and Low-CASA groups based on computer-assisted sperm analysis (CASA) parameters. LC–MS/MS analysis identified 817 seminal plasma proteins, of which differentially abundant proteins were associated with sperm motility, viability, mitochondrial activity and DNA fragmentation. Integrated bioinformatic analyses, including differential abundance analysis, protein–phenotype correlations, Gene Ontology enrichment and STRING network analysis, revealed oxidative stress–associated proteomic remodeling linked to sperm functional status. The dataset provides insight into seminal plasma molecular mechanisms associated with stallion reproductive performance. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-25 |
| AnnouncementXML | Submission_2026-05-25_15:36:41.117.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD078825 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Grzegorz Smolucha |
| SpeciesList | scientific name: Equus caballus (Horse); NCBI TaxID: NEWT:9796; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Orbitrap Exploris 240 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-05-25 14:25:45 | ID requested | |
| ⏵ 1 | 2026-05-25 15:36:41 | announced | |
Publication List
Keyword List
| submitter keyword: proteomics, sperm motility, seminal plasma, mitochondrial dysfunction, LFQ, oxidative stress,stallion, CASA |
Contact List
| Grzegorz Smolucha |
|---|
| contact affiliation | Department of Animal Molecular Biology Laboratory of Molecular Genetics Laboratory of Proteomics National Research Institute of Animal Production 1, Krakowska Street e-mail: grzegorz.smolucha@iz.edu.pl mobile: +48 666081204 32-083 Balice near Kraków |
| contact email | grzegorz.smolucha@iz.edu.pl |
| lab head | |
| Grzegorz Smolucha |
|---|
| contact affiliation | National Research Institute of Animal Profuctio, Laboratory of Proteomics |
| contact email | grzegorz.smolucha@iz.edu.pl |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD078825
- Label: PRIDE project
- Name: Label-Free Quantitative Proteomics of Stallion Seminal Plasma Reveals Oxidative Stress–Associated Protein Signatures Linked to Sperm Motility and Viability
