PXD078537-1

PXD078537 is an original dataset announced via ProteomeXchange.

Title	An autonomous bioelectronic suture that programs tendon regeneration through endogenous electromechanical-cues
Description	Tendon injuries disrupt the physiological equilibrium between mechanical stability and joint mobility, often resulting in persistent functional impairment. The regeneration of tendons with mature architecture and full biomechanical functionality remains a pivotal challenge in current clinical treatment and tissue repair. Here we introduce a self-powered, biomimetic electronic suture (BSE-suture) that converts physiological motion into adaptive bioelectrical and cellular regulation for accelerated tendon regeneration. The platform integrates a hierarchically organized architecture with a stem cell-laden hydrogel interface, enabling simultaneous mechanical compliance, autonomous electromechanical transduction, and local biological control. The suture matches the tensile performance of clinical sutures while minimizing interfacial friction and maintaining robust structural integrity. Under tendon-relevant deformation, it generates stable electrical outputs (~4 V, ~110 mV mm⁻¹) without external power sources. This self-generated stimulation preserves stem cell viability, directs tenogenic fate commitment and enhances regenerative signaling. In a rat Achilles tendon defect model, the SBE-suture markedly improved collagen organization, promoted functional tissue remodelling, and restored locomotor performance. The platform further reshapes the immune microenvironment by biasing macrophage polarization toward a reparative phenotype. By transforming sutures from passive mechanical fixators into active bioelectronic regulators, this work introduces a new class of self-adaptive regenerative implants that dynamically couple biomechanics with tissue regeneration in mechanically active organs.
HostingRepository	iProX
AnnounceDate	2026-05-18
AnnouncementXML	Submission_2026-05-19_00:01:20.791.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xingyi Wan
SpeciesList	scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Astral

Revision	Datetime	Status	ChangeLog Entry
0	2026-05-19 00:01:01	ID requested
⏵ 1	2026-05-19 00:01:21	announced

Dataset with its publication pending

submitter keyword: biomimetic electronic suture, stem cell, electromechancial stimulation, tendon regeneration

Yuqi Zhang
contact affiliation	Zhejiang University
contact email	yqzhang21@zju.edu.cn
lab head
Xingyi Wan
contact affiliation	Zhejiang University
contact email	wanxingyi@zju.edu.cn
dataset submitter

iProX dataset URI