⮝ Full datasets listing
PXD078308-1
PXD078308 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | In vivo profiling of astrocyte secretome reveals brain-region specific regulatory networks in a mouse model of amyloid pathology-Astrocyte |
| Description | Coordinated cell-to-cell communications is crucial for the proper functioning and maintenance of brain activities, and its disruption contributes to neurological disorders, including Alzheimer’s disease (AD). Altered astrocyte-neuron communications have been implicated in AD progression, yet the underlying regulatory networks remain poorly understood. Given that secretory proteins mediate both local and long-range intercellular signaling, we constructed a spatiotemporal profile of the astrocyte-derived secretome using in vivo TurboID proximity labeling in mice across the AD continuum. Early alterations in the entorhinal cortex secretome were identified and enriched in metabolic pathways, whereas changes in the hippocampus were observed later, correlating with neuronal and synaptic maintenance. These findings suggest that early remodeling of the astrocyte secretome in the entorhinal cortex may serve as an initiator of AD pathogenesis, while later changes in the hippocampus contribute to neurodegeneration and cognitive decline. This work provides a systematic map of the dynamic, region-specific remodeling of the astrocyte secretome in AD, identifying novel spatiotemporal vulnerabilities and potential therapeutic targets. |
| HostingRepository | iProX |
| AnnounceDate | 2026-05-13 |
| AnnouncementXML | Submission_2026-05-13_20:07:06.886.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Qiu Jiang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-05-13 20:06:42 | ID requested | |
| ⏵ 1 | 2026-05-13 20:07:07 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: AD astrocyte secretome |
Contact List
| Yanjiang Wang | |
|---|---|
| contact affiliation | Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University) |
| contact email | yanjiang_wang@tmmu.edu.cn |
| lab head | |
| Qiu Jiang | |
| contact affiliation | Army Medical University (Third Military Medical University) |
| contact email | 18113105655@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
