⮝ Full datasets listing
PXD078161-1
PXD078161 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Targeting Cellular Senescence Mitigates Chemotherapy-Induced Bone Loss in Young and Aged Mice |
| Description | Chemotherapy-induced bone loss represents a major clinical challenge, particularly in aging populations, yet the underlying mechanisms and effective therapeutic strategies remain incompletely understood. Here, we investigated the role of chemotherapy-indcued cellular senescence in mediating skeletal deterioration following chemotherapy and evaluated the therapeutic potential of senolytic treatment. Young (3-month-old) and aged (20-month-old) male and female mice were treated with doxorubicin (DX), dasatinib plus quercetin (DQ), or their combination (DX/DQ). Chemotherapy induced hallmark features of accelerated skeletal aging, including trabecular bone loss, increased marrow adiposity, and upregulation of senescence-associated and inflammatory gene expression. These effects were more pronounced in females and varied with age. Senolytic treatment partially restored osteogenic gene expression, including Alpl, Runx2, and Dmp1, and reduced marrow adiposity, particularly in aged females, indicating preservation of bone marrow niche function. Proteomic analysis of cortical bone revealed that DX-induced senescence was associated with extracellular matrix remodeling and a metabolic shift toward glycolysis, characterized by increased inflammatory collagen isoforms and glycolytic enzymes. DQ treatment reversed these molecular signatures, restoring key structural proteins such as Collagen 1A1, Collagen 11 isoforms, Asporin, and Osteomodulin. Despite these molecular improvements, structural recovery of trabecular bone was modest, suggesting that molecular remodeling precedes detectable changes in bone architecture. Collectively, these findings support a model in which chemotherapy-induced bone loss results from both early osteoblast suppression and senescence-driven microenvironmental dysfunction. Targeting senescent cells represents a promising strategy to mitigate aspects of skeletal aging and preserve bone health following chemotherapy. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-08-14 |
| AnnouncementXML | Submission_2026-08-14_11:55:07.575.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Charles Schurman |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | ZenoTOF 7600+ |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-05-08 17:13:36 | ID requested | |
| ⏵ 1 | 2026-08-14 11:55:08 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: bone, senolytics, proteomics, aging, DatasetType:Proteomics |
Contact List
| Birgit Schilling | |
|---|---|
| contact affiliation | Buck Institute |
| contact email | bschilling@buckinstitute.org |
| lab head | |
| Charles Schurman | |
| contact affiliation | Buck Institute for research On Aging |
| contact email | cschurman@buckinstitute.org |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v13/MSV000101777/ |
