PXD078154-1

PXD078154 is an original dataset announced via ProteomeXchange.

Title	Novel phenotypes of immune-mediated necrotizing myopathy identified independent of myositis-specific antibody specificity that improve prognostic stratification
Description	Immune-mediated necrotizing myopathy (IMNM) is a severe autoimmune myopathy with high clinical heterogeneity. Current classification relies on myositis-specific antibodies (MSA: anti-HMGCR, anti-SRP) but fails to explain differences in manifestations, interstitial lung disease (ILD) incidence, and survival. We enrolled 133 IMNM patients, used unsupervised machine learning (MSA-independent) to identify three phenotypes: Phenotype 1 (56.4%, muscle weakness, favorable prognosis), Phenotype 2 (10.5%, high muscle damage indicators, intermediate prognosis), Phenotype 3 (33.1%, high ILD/mortality, poor prognosis). Label-free DIA quantitative proteomics on these phenotypes and noninflammatory controls revealed distinct protein expression patterns, providing molecular evidence for IMNM subtyping, mechanism exploration, and prognosis evaluation.
HostingRepository	iProX
AnnounceDate	2026-05-06
AnnouncementXML	Submission_2026-05-12_00:24:15.559.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xuefan Yu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 240

Revision	Datetime	Status	ChangeLog Entry
0	2026-05-08 02:33:16	ID requested
⏵ 1	2026-05-12 00:24:16	announced

Dataset with its publication pending

submitter keyword: immune-mediated necrotizing myopathy

XuefanYu
contact affiliation	The First Affiliated Hospital of Jilin University
contact email	xuefan@jlu.edu.cn
lab head
Xuefan Yu
contact affiliation	The First Affiliated Hospital of Jilin University
contact email	xuefan@jlu.edu.cn
dataset submitter

iProX dataset URI