PXD078091 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | RNA polymerase I, II, III CoIP ms/ms |
| Description | RNA polymerase III (Pol III) synthesizes noncoding RNAs essential for translation, RNA processing, transcription regulation, and other core cellular processes. Pol III transcription levels are coordinated with nutrient availability for cellular growth, and its dysregulation is linked to disease, such as breast cancer and leukodystrophy. Despite its importance, human Pol III regulatory mechanisms remain largely uncharacterized, in part due to limited exploration of Pol III-centered protein-protein interactions (PPIs). To address this gap, we surveyed the Pol III complex interactome by leveraging a series of Pol III-specific subunit pull-down and mass spectrometry experiments. We identified over 300 novel Pol III interactors, including Pol II-related transcription factors, nuclear import factors, and splicing factors. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-09-03 |
| AnnouncementXML | Submission_2026-09-03_00:01:10.472.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD078091 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Ruiying Cheng |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | biotinylated residue; phosphorylated residue; acetylated residue; monohydroxylated residue |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-05-06 20:18:39 | ID requested | |
| ⏵ 1 | 2026-09-03 00:01:11 | announced | |
Publication List
Keyword List
| submitter keyword: Human, PPI, RNA polymerase |
Contact List
| Kevin Van Bortle |
|---|
| contact affiliation | Department of Cell and Developmental Biology, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA Cancer Center at Illinois, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA |
| contact email | kvbortle@illinois.edu |
| lab head | |
| Ruiying Cheng |
|---|
| contact affiliation | University of Illinois Urbana-Champaign |
| contact email | rcheng14@illinois.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD078091 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD078091
- Label: PRIDE project
- Name: RNA polymerase I, II, III CoIP ms/ms
