PXD077920 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic Characterisation of Human Osteoblast-Derived Decellularised Extracellular Matrix for Osteogenic Repair |
| Description | This project investigated cell-derived extracellular matrix (ECM) preparation for matrix-guided bone tissue engineering. A detergent-based decellularisation protocol using NH4OH and Triton X-100 was optimised using fibroblast-derived ECM to improve DNA removal while preserving ECM-associated protein content. To provide a more bone-relevant molecular reference, the same decellularisation approach was also applied to HOB-derived ECM. Proteomic analysis of HOB-derived dECM identified ECM-associated proteins linked to osteogenic activity, including collagens, laminins, annexins, and calcium-binding proteins. This dataset is presented as a descriptive reference for osteoblast-derived ECM composition, rather than as a direct comparison with the fibroblast-derived ECM used in functional assays. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-26 |
| AnnouncementXML | Submission_2026-05-26_10:36:15.126.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD077920 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Agata Szubska |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | Oxidation; acetylated residue; Carbamidomethyl |
| Instrument | Orbitrap Ascend |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-05-01 10:25:59 | ID requested | |
| ⏵ 1 | 2026-05-26 10:36:15 | announced | |
Publication List
Keyword List
Contact List
| Lucy Di Silvio |
|---|
| contact affiliation | Centre for Oral, Clinical and Translational Science, King's College London, London, United Kingdom |
| contact email | lucy.di_silvio@kcl.ac.uk |
| lab head | |
| Agata Szubska |
|---|
| contact affiliation | King's College London |
| contact email | agata.szubska@kcl.ac.uk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077920 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD077920
- Label: PRIDE project
- Name: Proteomic Characterisation of Human Osteoblast-Derived Decellularised Extracellular Matrix for Osteogenic Repair
