PXD077846-1

PXD077846 is an original dataset announced via ProteomeXchange.

Title	Sleeve Gastrectomy Is Associated with Improvement of Obesity-Associated T2DM Through Suppression of the Ghrelin-GHSR Signaling Axis, Reshaping of Hypothalamic POMC Neuronal Activity, and Reprogramming of CD4+ T Cell Metabolic Immunity
Description	This study highlights a cross-system regulatory axis linking the Ghrelin-GHSR pathway to hypothalamic POMC neuronal activity and peripheral CD4+ T-cell metabolic reprogramming in obesity-associated T2DM. While SG is clinically effective, its weight-independent mechanisms remain incompletely defined. Here, our data support that SG is associated with a coordinated shift in CD4+ T-cell energetics from glycolysis toward oxidative phosphorylation through suppression of Ghrelin-GHSR signaling, thereby helping restore Treg/Th17 balance and systemic redox homeostasis.
HostingRepository	iProX
AnnounceDate	2026-04-29
AnnouncementXML	Submission_2026-04-30_00:12:58.097.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xin Li
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2026-04-30 00:09:17	ID requested
⏵ 1	2026-04-30 00:12:58	announced

Dataset with its publication pending

submitter keyword: Sleeve Gastrectomy

Weihui Liu
contact affiliation	University of Electronic Science and Technology of China
contact email	lx3741641@uestc.edu.cn
lab head
Xin Li
contact affiliation	University of Electronic Science and Technology of China
contact email	1545559471@qq.com
dataset submitter

iProX dataset URI