⮝ Full datasets listing
PXD077834-1
PXD077834 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Mitochondrial Legumain sustains mitochondrial homeostasis and oxaliplatin resistance in colorectal cancer |
| Description | This project contains DIA-based quantitative proteomics data generated from cultured HCT116 colorectal cancer cells treated with DMSO or LZ-A4. Proteomic profiling was performed on an Orbitrap Astral mass spectrometry platform to characterize global protein expression changes associated with pharmacologic depletion of legumain, with a particular focus on mitochondrial ribosomal proteins, oxidative phosphorylation components, and mitochondrial stress-related pathways in colorectal cancer cells. |
| HostingRepository | iProX |
| AnnounceDate | 2026-04-28 |
| AnnouncementXML | Submission_2026-06-15_20:23:19.675.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hongguang Xia |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-04-29 20:34:03 | ID requested | |
| ⏵ 1 | 2026-06-15 20:23:20 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: LGMN mitochondria tumor chaperone |
Contact List
| Hongguang Xia | |
|---|---|
| contact affiliation | Zhejiang University |
| contact email | hongguangxia@zju.edu.cn |
| lab head | |
| Hongguang Xia | |
| contact affiliation | Zhejiang University |
| contact email | fqwang@zju.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
