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PXD077765-1

PXD077765 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleRat infected Lung by Cryptococcus deuterogattii R265
DescriptionCryptococcosis caused by Cryptococcus deuterogattii is a life-threatening fungal infection increasingly reported in immunocompetent individuals. In this analysis we perfomed an experimental infection in adults rats to elucidate molecular alterations in this disease. For experimental infection, rats (n = 6 per group) were anesthetized with intraperitoneal ketamine (75 mg/kg) and xylazine (10 mg/kg). They were divided into: (i) control (no inoculation), (ii) infected intranasally with 0.1 mL of 1 × 10⁹ C. deuterogattii R265 cells for analysis at 3 days post-inoculation (dpi), (iii) same inoculation for analysis at 14 dpi, (ii) infected intranasally with 0.1 mL of 1 × 10⁹ C. deuterogattii R265 cells for analysis at 3 days post-inoculation (dpi), and (iii) same inoculation for analysis at 14 dpi. At 3 and 14 dpi, rats were re-anesthetized, thoracic cavity opened, and lungs removed. Left lungs for proteomic analysis.
HostingRepositoryPRIDE
AnnounceDate2026-05-13
AnnouncementXMLSubmission_2026-05-13_08:50:06.590.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterLaura Saciloto
SpeciesList scientific name: Rattus norvegicus (Rat); NCBI TaxID: NEWT:10116;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ XL
Dataset History
RevisionDatetimeStatusChangeLog Entry
02026-04-28 17:28:43ID requested
12026-05-13 08:50:07announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: proteomics, Cryptococcosis,Lung, rattus novergicus, Cryptococcus
Contact List
Walter Orlando Beys da Silva
contact affiliationUniversidade Federal do Rio Grande do Sul (UFRGS), Laboratório de Microbiologia Molecular e Proteômica (LAMMOP), Faculdade de Farmácia
contact emailwalter.beys@ufrgs.br
lab head
Laura Saciloto
contact affiliationUniversidade de Campinas
contact emailsacilotolaura@gmail.com
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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