⮝ Full datasets listing
PXD077557-1
PXD077557 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Comparative Analysis of Molecular Signatures in High-Fat and High-Fat, High-Fructose Diet–Induced Fatty Liver in Mice Based on Integrated Transcriptomic and Proteomic Profiling |
| Description | Objective To evaluate and compare the metabolic and hepatic multi-omics responses of mice to a high-fat diet (HFD) and a high-fat/high-fructose diet (HFHFD), and to preliminarily identify shared as well as diet-specific alterations at both the pathway and candidate molecular levels, thereby providing further insight into Metabolic dysfunction–associated steatotic liver disease-associated metabolic remodeling Methods Twenty-one male C57BL/6J mice were randomly divided into three groups:a standard diet, HFD, or HFHFD group (n = 7 per group) and were fed for 8 weeks. Systemic metabolic phenotypes were assessed, including changes in body mass, glucose metabolism, and lipid profiles. Hepatic steatosis and liver injury were evaluated by measuring hepatic triglyceride content, serum ALT/AST levels, and conducting histological analyses. Integrated hepatic transcriptomic and proteomic analyses were performed, with key molecules validated by qRT-PCR.. |
| HostingRepository | iProX |
| AnnounceDate | 2026-04-24 |
| AnnouncementXML | Submission_2026-04-23_19:20:26.210.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xinming Cao |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-04-23 19:19:36 | ID requested | |
| ⏵ 1 | 2026-04-23 19:20:26 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Metabolic dysfunction-associated steatotic liver disease;High-Fat ,High-Fructose Diet |
| Metabolic |
Contact List
| Luping Ren | |
|---|---|
| contact affiliation | Hebei General Hospital |
| contact email | renluping1122@163.com |
| lab head | |
| Xinming Cao | |
| contact affiliation | Hebei North University |
| contact email | 15613516050@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
