PXD077461 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Complement C3 Deficiency Attenuates Renal Ischemia–Reperfusion Injury and Reveals Distinct Molecular Signatures Compared with C5 Deletion |
| Description | Ischemia–reperfusion injury (IRI) is a major cause of acute kidney injury and can lead to chronic kidney disease, with the complement system playing a key role, though the relative importance of early (C3) versus late (C5) components is unclear. In this study, IRI was induced in rats lacking C3 or C5, and kidney function, tissue damage, and proteomic changes were analyzed. Both C3 and C5 knockout rats showed strong protection, including improved kidney function, reduced tissue damage, and lower injury markers (KIM-1 and NGAL). C3 deficiency mainly enhanced metabolic and energy pathways while suppressing immune responses, whereas C5 deficiency primarily affected tissue remodeling with modest immune effects. Overall, blocking C3 had broader effects on kidney injury and repair than blocking C5, although both reduced damage, suggesting that targeting different parts of the complement system may offer therapeutic benefits. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-09-07 |
| AnnouncementXML | Submission_2026-09-07_04:21:37.862.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD077461 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Dinesh Bhattarai |
| SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: NEWT:10116; |
| ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | quadrupole orbitrap astral instrument |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-04-21 20:50:33 | ID requested | |
| ⏵ 1 | 2026-09-07 04:21:40 | announced | |
Publication List
| 10.6019/PXD077461; |
| Bhattarai D, Sharma A, McGraw M, Jun SR, Joshi N, Gokden N, Mackintosh S, Parajuli N, Effect of complement 3/5 knockout on renal proteomics landscape after ischemia and reperfusion injury in rats. Physiol Rep, 14(14):e71017(2026) [pubmed] |
| 10.14814/phy2.71017; |
Keyword List
| submitter keyword: Ischemia-reperfusion injury, Complement C5, Kidney transplantation, Acute Kidney injury, Proteomics, Complement C3 |
Contact List
| Nirmala Parajul |
|---|
| contact affiliation | University of Arkansas for Medical Science |
| contact email | nparajuli@uams.edu |
| lab head | |
| Dinesh Bhattarai |
|---|
| contact affiliation | University of Arkansas for Medical Science |
| contact email | dbhattarai@uams.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD077461
- Label: PRIDE project
- Name: Complement C3 Deficiency Attenuates Renal Ischemia–Reperfusion Injury and Reveals Distinct Molecular Signatures Compared with C5 Deletion
