PXD077366-1

PXD077366 is an original dataset announced via ProteomeXchange.

Title	Fatty Acid Metabolism Reprograms Immune Microenvironment in Retinal Artery Occlusion: Multi-Omics Analysis Highlights Immunometabolic Crosstalk
Description	This dataset contains integrated multi-omics data from a study investigating fatty acid metabolism and immune dysregulation in retinal artery occlusion (RAO). Data include serum metabolomics profiles, peripheral blood mononuclear cell (PBMC) transcriptomics, and immune phenotyping from 66 RAO patients (34 with dyslipidemia, 32 without) and 66 cataract controls. Analytical methods applied include multivariate analyses (sPLS-DA, OPLS-DA), random forest modeling, and SHAP evaluations to identify key metabolic and immune features. The dataset highlights differential fatty acid metabolites (e.g., C22:5n-3, C22:2n-6, C22:1n-9, C20:2n-6), associated gene expression changes, and immune cell alterations (elevated neutrophils, reduced lymphocytes). The data support exploration of metabolic–immune crosstalk in RAO pathogenesis and provide resources for biomarker discovery and therapeutic target validation.
HostingRepository	iProX
AnnounceDate	2026-04-19
AnnouncementXML	Submission_2026-04-28_20:40:03.498.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ying Li
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	electrospray ionization; quadrupole

Revision	Datetime	Status	ChangeLog Entry
0	2026-04-19 20:06:30	ID requested
⏵ 1	2026-04-28 20:40:04	announced

Dataset with its publication pending

submitter keyword: Ophthalmology, Metabolomics, Immunology

Ying Li
contact affiliation	Wuhan University
contact email	li_ying86@126.com
lab head
Ying Li
contact affiliation	Renmin Hospital of Wuhan University
contact email	li_ying86@126.com
dataset submitter

iProX dataset URI