PXD077257-1

PXD077257 is an original dataset announced via ProteomeXchange.

Title	LC-MSMS measurements of paired human lung tumor/tumor-free tissues with serial dilutions
Description	This dataset is included as one of the benchmarking dataset in the manuscript "msBayesImpute: A Versatile Framework for Addressing Missing Values in Biomedical Mass Spectrometry Proteomics Data" by He et al (https://www.biorxiv.org/content/10.1101/2025.10.02.679746v1). To better recapture the missing value pattern in a real-world situation, the missing values were experimentally introduced through mass-spectrometry measurements of lysates of 20 paired tumour/tumour-free tissues from 10 lung cancer patients without dilution and with dilution fractions of 75% and 50%.
HostingRepository	PRIDE
AnnounceDate	2026-09-07
AnnouncementXML	Submission_2026-09-07_04:21:41.226.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Junyan Lu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2026-04-16 11:42:29	ID requested
⏵ 1	2026-09-07 04:21:42	announced

10.1038/s42004-026-02106-3;

He J, Helm B, G, ö, dtel F, B, ü, chner K, Schilling M, Schneider MA, Klotz LV, Braunger J, Winter H, Velten B, Klingm, ü, ller U, Lu J, msBayesImpute as a versatile framework for addressing missing values in biomedical mass spectrometry proteomics data. Commun Chem, 9(1):(2026) [pubmed]

submitter keyword: Human, LC-MSMS, serial dilution, lung

Ursula Klingmüller
contact affiliation	Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany
contact email	U.Klingmueller@dkfz-heidelberg.de
lab head
Junyan Lu
contact affiliation	European Molecular Biology Laboratory
contact email	junyan.lu@embl.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD077257

PRIDE project URI

• PRIDE
  1. PXD077257
     1. Label: PRIDE project
     2. Name: LC-MSMS measurements of paired human lung tumor/tumor-free tissues with serial dilutions