PXD077246-1

PXD077246 is an original dataset announced via ProteomeXchange.

Title	LC-MS on porcine pancreatic remodeling
Description	The pancreatic endocrine cells, particularly the insulin secreting β-cells, adapt to pregnancy by increasing cell mass, size and altering secretory patterns. Since most studies utilize rodent models, translating findings to human pregnancy remains challenging. In this work, we performed an extensive characterization of pancreatic adaptations throughout pig pregnancy. Pigs have long gestational cycles (114 days) as well as similar size and metabolism to humans. By analyzing pancreatic samples from early and late gestation ages, we captured the full trajectory of endocrine remodeling. We observed that pregnancy induces selective endocrine cell-type remodeling, marked by preferential expansion of pancreatic polypeptide cells. Proteomic characterization of pancreata from early and late gestation showed a downregulation of SLC20A2 and ZCCHC7, identifying new targetable proteins for physiological endocrine cell adaptation. Overall, our comprehensive characterization of pancreatic adaptations in the pig model bridges the translational gap between rodents and humans and highlights new proteins with therapeutic potential in gestational diabetes.
HostingRepository	PRIDE
AnnounceDate	2026-05-26
AnnouncementXML	Submission_2026-05-25_23:35:19.909.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Christine von Toerne
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: NEWT:9825;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF HT

Revision	Datetime	Status	ChangeLog Entry
0	2026-04-16 08:19:23	ID requested
⏵ 1	2026-05-25 23:35:20	announced

Dataset with its publication pending

submitter keyword: pancreas,ZCCHC7,LC-MS, SLC20A2, porcine

Heiko Lickert
contact affiliation	Institute of Diabetes and Regeneration Research, Helmholtz Munich, Neuherberg, Germany
contact email	heiko.lickert@helmholtz-munich.de
lab head
Christine von Toerne
contact affiliation	Helmholtz Zentrum München
contact email	vontoerne@helmholtz-muenchen.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077246

PRIDE project URI

• PRIDE
  1. PXD077246
     1. Label: PRIDE project
     2. Name: LC-MS on porcine pancreatic remodeling