⮝ Full datasets listing
PXD077233-1
PXD077233 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Arid3b suppresses CD8+ T cell infiltration and function in Microsatellite-stable colorectal cancer via Runx3 |
| Description | Microsatellite stable/proficient mismatch repair (MSS/pMMR) colorectal cancer (CRC) is characterized by a cold tumor microenvironment, marked by sparse CD8⁺ T cell infiltration and resistance to immune checkpoint inhibitors (ICIs). To uncover regulators that limit CD8⁺ T cell infiltration in MSS CRC, we conducted an in vivo CRISPR/Cas9 screen targeting genes in CD8⁺ T cells using a CMT93 cell-derived tumor model. This screen identified Arid3b as a key negative regulator of CD8⁺ T cell tumor infiltration and antitumor activity. Genetic ablation of Arid3b in CD8⁺ T cells significantly enhanced their intratumoral accumulation and mediated robust tumor control. Mechanistically, Arid3b deficiency upregulated Runx3, promoting a tissue-resident memory phenotype and effector function. Notably, the benefits conferred by Arid3b knockout were abrogated by Runx3 deletion, indicating a Runx3-dependent mechanism. In summary, targeting ARID3B could offer a promising strategy to reshape the tumor microenvironment and sensitize MSS CRC to immunotherapy. |
| HostingRepository | iProX |
| AnnounceDate | 2026-04-16 |
| AnnouncementXML | Submission_2026-04-16_02:32:39.127.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Shuo Wang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-04-16 02:29:06 | ID requested | |
| ⏵ 1 | 2026-04-16 02:32:39 | announced | |
| 2 | 2026-06-01 19:33:44 | announced | 2026-06-02: Add info |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: ARID3B, IP/MS, CD8+ T cell, MSS, colorectal cancer |
Contact List
| Zhidong Gao | |
|---|---|
| contact affiliation | Peking University People’s Hospital |
| contact email | gaozhidong@pkuph.edu.cn |
| lab head | |
| Shuo Wang | |
| contact affiliation | Peking University People’s Hospital |
| contact email | dr_shuowang@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
